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©The Author(s) 2015.
World J Gastroenterol. Aug 14, 2015; 21(30): 9163-9174
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9163
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9163
Table 5 Haematological adverse events n (%)
All patients | Boceprevir | Telaprevir | P value | Non-F4 | F4 | P value | |
Neutropaenia | n = 943 | n = 360 | n = 583 | n = 369 | n = 505 | ||
Grade 0-1-2: | 707 (75) | 241 (67) | 466 (80) | 0 | 289 (78) | 370 (73) | NS |
> 750 μL | |||||||
Grade 3-4: | 236 (25) | 119 (33) | 117 (20) | 80 (22) | 135 (27) | ||
≤ 750 μL | |||||||
Thrombocytopaenia | n = 935 | n = 359 | n = 576 | n = 365 | n = 501 | ||
Grade 0-1-2: | 0.000 | ||||||
> 50.000 μL | 753 (81) | 293 (82) | 460 (80) | NS | 337 (92) | 371 (74) | |
Grade 3-4: | |||||||
≤ 50.000 μL | 182 (20) | 66 (18) | 116 (20) | 28 (8) | 130 (26) | ||
Anaemia | n = 1036 | n = 397 | n = 639 | n = 411 | n = 539 | ||
Grade 0-1-2: | 943 (91) | 367 (92) | 576 (90) | NS | 384 (93) | 481 (89) | 0.025 |
> 8 g/dL | |||||||
Grade 3-4: | 93 (9) | 30 (8) | 63 (10) | 27 (7) | 58 (11) | ||
< 8 g/dL | |||||||
Transfusion | n = 1036 | n = 397 | n = 639 | 0.001 | n = 411 | n = 539 | NS |
150 (15) | 39 (10) | 111 (17) | 49 (12) | 85 (16) | |||
EPO | n = 1033 | n = 396 | n = 637 | 0 | n = 410 | n = 539 | NS |
218 (21) | 60 (15) | 158 (25) | 75 (18) | 117 (22) | |||
Onset of anaemia ( ≤ 9.5 g/dL) | 12 ± 8 | 15 ± 11 | 9.5 ± 6.1 | 0 | 11.3 ± 7.2 | 11.5 ± 9 | NS |
- Citation: Salmerón J, Vinaixa C, Berenguer R, Pascasio JM, Sánchez Ruano JJ, Serra M&, Gila A, Diago M, Romero-Gómez M, Navarro JM, Testillano M, Fernández C, Espinosa D, Carmona I, Pons JA, Jorquera F, Rodriguez FJ, Pérez R, Montero JL, Granados R, Fernández M, Martín AB, Muñoz de Rueda P, Quiles R, Alhambra Spanish Study Group. Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis. World J Gastroenterol 2015; 21(30): 9163-9174
- URL: https://www.wjgnet.com/1007-9327/full/v21/i30/9163.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i30.9163