Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis

doi:10.3748/wjg.v21.i30.9163

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Aug 14, 2015 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2015; 21(30): 9163-9174
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9163

Table 1 Group of patients according to hepatitis C virus treatment history n (%)

	All patients	BOC	TVR	P value	Fibrosis	Non-F4	F4	P value
	(n = 1057) (100)	(n = 405) (38)	(n = 652) (62)		All patients	(n = 423) (44)	(n = 545) (56)
	(n = 1057) (100)	(n = 405) (38)	(n = 652) (62)		(n = 958) (100)	(n = 423) (44)	(n = 545) (56)
TN	319 (30)	130 (32)	189 (29)	0.000	294 (30)	129 (31)	165 (30)	0.010
TE	738 (70)	275 (68)	463 (71)		664 (70)	294 (67)	380 (70)
R	298 (28)	77 (19)	221 (34)		270 (28)	138 (33)	132 (24)
PR	123 (12)	55 (14)	68 (10)		113 (12)	44 (10)	69 (13)
NR	260 (25)	119 (29)	141 (22)		238 (25)	86 (20)	152 (28)
Unknown responders	57 (5)	24 (6)	33 (5)		53 (6)	26 (6)	27 (5)

Bivariate analysis: χ² tests. TN: Treatment-naïve; TE: Treatment-experienced; R: Relapsers; PR: Partial responders; NR: Null responders; Unknown responders: Treatment-experienced with response unknown.

Citation: Salmerón J, Vinaixa C, Berenguer R, Pascasio JM, Sánchez Ruano JJ, Serra M&, Gila A, Diago M, Romero-Gómez M, Navarro JM, Testillano M, Fernández C, Espinosa D, Carmona I, Pons JA, Jorquera F, Rodriguez FJ, Pérez R, Montero JL, Granados R, Fernández M, Martín AB, Muñoz de Rueda P, Quiles R, Alhambra Spanish Study Group. Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis. World J Gastroenterol 2015; 21(30): 9163-9174
URL: https://www.wjgnet.com/1007-9327/full/v21/i30/9163.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i30.9163