Pre-lung transplant measures of reflux on impedance are superior to pH testing alone in predicting early allograft injury

Table 1 Baseline characteristics demonstrating homogeneity of the pulmonary transplant study population

	Total	Normal distal reflux exposure	Increased distal reflux exposure
	(n = 32)	(n = 13)	(n = 19)
Follow-up (yr), median	1.3
Male sex	15 (46.9)	7 (53.8)	8 (42.1)
BMI, mean ± SD	26.7 ± 4.97	26.7 ± 4.47	26.7 ± 5.40
Age at transplant (yr), mean	54.7 ± 10.8	57.6 ± 9.01	52.7 ± 11.7
White race	30 (93.7)	13 (100)	17 (89.5)
Pulmonary diagnosis
IPF	15 (46.9)	3 (23.1)	12 (63.2)
COPD	6 (18.7)	3 (23.1)	3 (15.8)
CF	6 (18.7)	2 (15.4)	4 (21.0)
COP	2 (6.25)	2 (15.4)	0
AAT	1 (3.13)	1 (7.69)	0
Sarcoid	1 (3.13)	1 (7.69)	0
Other	1 (3.13)	1 (7.69)	0
Cardiac function, Baseline
LVH
None	27 (84.4)	11 (84.6)	16 (84.2)
Any	5 (15.6)	2 (15.4)	3 (15.8)
LVEF, mean ± SD	0.59 ± 0.05	0.58 ± 0.06	0.60 ± 0.05
PCWP, mean ± SD	9.97 ± 4.62	11.5 ± 4.99	8.89 ± 4.15
PVR1, mean ± SD	224.4 ± 89.0	243.3 ± 100.1	210.0 ± 79.6
Pulmonary function, Baseline
FVC	1.91 ± 0.71	2.00 ± 0.84	1.85 ± 0.63
FVC, %-pred	0.48 ± 0.14	0.50 ± 0.16	0.47 ± 0.12
FEV1	1.22 ± 0.60	1.07 ± 0.67	1.32 ± 0.54
FEV1, %-pred	0.39 ± 0.18	0.33 ± 0.17	0.43 ± 0.17
FEV1/FVC	0.65 ± 0.24	0.54 ± 0.24	0.73 ± 0.21
Lungs transplanted
Unilateral	15 (46.9)	7 (53.8)	8 (42.1)
Bilateral	17 (53.1)	6 (46.1)	11 (57.9)
Post-transplant PPI	24 (75.0)	10 (76.9)	14 (73.7)
Deaths, all cause	8 (25.0)	2 (15.4)	6 (31.6)
Deaths, pulmonary-related	7 (21.9)	2 (15.4)	5 (26.3)
Early allograft injury	16 (50.0)	5 (38.5)	11 (57.9)
BOS	2 (6.25)	1 (7.69)	1 (5.26)

¹PVR was not measured in two subjects. BMI: Body mass index; IPF: Idiopathic pulmonary fibrosis; COPD: Chronic obstructive pulmonary disease; CF: Cystic fibrosis; COP: Cryptogenic organizing pneumonia; AAT: Alpha-1-antitrypsin deficiency; LVH: Left ventricular hypertrophy; LVEF: Left ventricular ejection fraction; PCWP: Pulmonary capillary wedge pressure; PVR: Pulmonary vascular resistance; FVC: Forced vital capacity; %-pred: Percent of predicted value; FEV1: Forced expiratory volume in 1 second; PPI: Proton pump inhibitor; BOS: Bronchiolitis obliterans syndrome.