Experimental infection of Z:ZCLA Mongolian gerbils with human hepatitis E virus

Figure 3 Histopathologic changes in the hepatitis E virus-inoculated Mongolian gerbils. A: A representative liver sample showing slight histiocytic hepatitis and focal accumulation of inflammatory cells surrounding hepatocytes [21 d post-inoculation (DPI)]; B: A representative spleen sample showing ruptured and enlarged splenocytes with multiple vacuolar degeneration (21 DPI); C: A representative kidney showing disarranged kidney cells with increased infiltrating lymphocytes and macrophages (35 DPI); D: A representative negative control liver; E: A representative negative control spleen; F: A representative Negative control kidney. All tissues were stained with hematoxylin and eosin. Original magnifications × 400.