Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats

Figure 4 Time course of nociceptive responses to mechanical and heat stimuli after a single systemic treatment with (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate. A, B: Animals were treated with a single ip dose of (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate (APDC) (3 mg/kg). APDC reversed the increase in nociception responses 1 h post treatment evoked by (A) low intensity (1 g) abdominal stimulation and (B) high intensity (6 g) abdominal stimulation; C: Alcohol and high fat (AHF) fed rats had increased hindpaw mechanical withdrawal thresholds; D: Response latencies of AHF fed rats increased 1 h after APDC treatment in the hotplate test, but sensitivity of the controls was not altered. ^aP < 0.05, AHF vs control.