Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats

Figure 3 Time course of nociceptive behaviors in rats with chronic pancreatitis evoked by mechanical and heat stimuli. A, B: Abdominal sensitivity is determined by the number of abdominal withdrawals in response to von Frey filament bending force stimulations (× 10). Responses to (A) low intensity (1 g) and (B) high intensity (6 g) mechanical stimulation elicited significantly more responses in alcohol and high fat (AHF) fed rats starting in week 5; C: Mechanical thresholds of the hindpaws were determined with von Frey filaments using the up-down method. In week 4 mechanical sensitivity thresholds of AHF fed rats were significantly reduced and did not recover while on the AHF diet; D: Heat sensitivity was determined by measuring the response latency (s) in the hotplate test (50 °C). In week 4, AHF fed rats demonstrated reduced response latencies in the hotplate test which did not recover during the 10 wk experimental time course. Open squares: control animals. Solid circles: AHF fed animals. ^aP < 0.05, AHF vs control.