Deficient DNA mismatch repair is associated with favorable prognosis in Thai patients with sporadic colorectal cancer

doi:10.3748/wjg.v21.i3.926

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2015; 21(3): 926-934
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.926

Table 7 Independent risk factors correlating with disease-free survival and overall survival of stage I-IV colorectal cancer patients by Cox’s proportional hazard regression analysis

	Adjusted analysis for DFS			Adjusted analysis for OS
Variable	HR	95%CI	P value	HR	95%CI	P value
Stage
Stage I¹
Stage II	1.23	0.43-3.62	0.702	1.47	0.40-5.40	0.559
Stage III	4.03^a	1.57-10.32	0.004^a	4.94^a	1.50-16.27	0.009^a
Stage IV	-			32.64^a	9.57-111.27	< 0.001^a
Invasion
No invasion¹
LVI/PNI/both	1.17	0.75-1.81	0.486	1.36	0.85-2.19	0.204
Differentiation
Well-moderate¹
Poorly	2.57	0.87-7.43	0.083	3.78	1.27-11.21	0.017^a
MMR status
pMMR¹
dMMR	0.30	0.15-0.77	0.013^a	0.29^a	0.10-0.84	0.023^a

¹Reference.

^aP < 0.05 vs control. DFS: Disease-free survival; OS: Overall survival; HR: Hazard ratio; MMR: Mismatch repair; pMMR: Proficient MMR; dMMR: Deficient MMR.

Citation: Korphaisarn K, Pongpaibul A, Limwongse C, Roothumnong E, Klaisuban W, Nimmannit A, Jinawath A, Akewanlop C. Deficient DNA mismatch repair is associated with favorable prognosis in Thai patients with sporadic colorectal cancer. World J Gastroenterol 2015; 21(3): 926-934
URL: https://www.wjgnet.com/1007-9327/full/v21/i3/926.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i3.926