Deficient DNA mismatch repair is associated with favorable prognosis in Thai patients with sporadic colorectal cancer

Table 6 Univariate analysis of prognostic factors influencing disease-free survival and overall survival

Variable	n	DFS		OS
		Median survival (mo)	P value	Median survival (mo)	P value
Gender
Female	105	NR		NR
Male	106	NR	0.528	NR	0.640
Age (yr)
≤ 50	30	NR		NR
> 50	181	NR	0.695	NR	0.424
Site
Right-sided	43	NR		NR
Left-sided	73	NR		NR
Rectum	91	NR		NR
Synchronous lesions	4	NR	0.682	NR	0.788
Stage
I	32	NR		NR
II	65	NR	< 0.0001a	NR	< 0.0001a
III	85	66.7	< 0.0001a	NR	< 0.0001a
IV	29	10.4	< 0.0001a	21.6	< 0.0001a
Invasion
No invasion	118	NR		NR
LVI or PNI or both	93	52.8	0.002a	57.13	< 0.0001a
Differentiation
Well-moderately	203	NR		NR
Poorly	8	29.83	0.575	40.67	0.306
Bowel wall invasion
pT1-T2	48	NR		NR
pT3	146	62.23	0.011a	NR	< 0.0001a
pT4	17	66.73	0.122	66.733	< 0.0001a
Lymph node metastasis
pN-	105	NR		NR
pN+	106	27.57	< 0.0001a	54	< 0.0001a
Distant metastasis
No	182	-	-	NR	< 0.0001a
Yes	29	-	-	21.6
BRAF status
Wild type	188	NR	0.794	NR	0.465
Mutation	23	NR		NR
MMR status
pMMR	177	NR	0.004a	NR	0.006a
dMMR	31	NR		NR

^aP < 0.05 vs control. DFS: Disease-free survival; OS: Overall survival; NR: Not reached; ALI: Angiolymphatic invasion; PNI: Perineural invasion; pT: Pathological tumor stage; pN: Pathological nodal stage; pMMR: Proficient mismatch repair; dMMR: Deficient MMR.