Deficient DNA mismatch repair is associated with favorable prognosis in Thai patients with sporadic colorectal cancer

Table 4 Association between mismatch repair/BRAF status and clinicopathological factors

	MMR status(n = 208)			BRAF status(n = 211)
Variable	pMMR	dMMR	P value	Wild type	Mutant	P value
Gender
Female	87	16	0.800	94	11	0.844
Male	90	15		94	12
Age (yr)
≤ 50	24	6	0.397	29	1	0.151
> 50	153	25		159	22
Site
Right-sided	31	11	0.037a	36	7	0.510
Left-sided	59	12		67	6
Rectum	84	7		81	10
Synchronous lesions	3	1		4	0
Stage
I	25	7	0.053	30	2	0.552
II	55	8		58	7
III	68	16		73	12
IV	29	0		27	2
Invasion
No	99	17	0.910	106	12	0.701
LVI or PNI or both	78	14		82	11
Differentiation
Well-moderately	172	28	0.067	180	23	0.313
Poorly	5	3		8	0
Bowel wall invasion
pT1	3	1	0.511	4	0	0.410
pT2	34	9		39	5
pT3	126	18		128	18
pT4	14	3		17	0
Lymph node metastasis
pN-	88	15	0.891	96	9	0.280
pN+	89	16		92	14
Distant metastasis
No	148	31	0.015a	161	21	0.456
Yes	29	0		21	2

^aP < 0.05 vs control. MMR: Mismatch repair; pT: Pathological tumor stage; pN: Pathological nodal stage; ALI: Angiolymphatic invasion; PNI: Perineural invasion.