RhoC, vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma

Table 2 Ras homolog C mRNA relative content, expression of Ras homolog C mRNA and protein and vascular endothelial growth factor protein in esophageal squamous cell carcinoma and the relationship with clinicopathologic parameters

Clinicopathologic parameters	Cases(n)	RhoC mRNA relative content	F(t, χ2)	P value	RhoC mRNA expression			χ2	P value	RhoC protein expression			χ2	P value	VEGF protein expression			χ2	P value
					-	+	Positive rate			-	+	Positive rate			-	+	Positive rate
Gender
Male	36	0.922 ± 0.123	0.586	0.118	7	29	80.6	0.000	0.983	6	30	83.3	0.018	0.892	11	25	69.4	0.004	0.950
Female	26	0.874 ± 0.109			5	21	80.8			4	22	84.6			9	17	65.4
Age (yr)
≥ 60	33	0.911 ± 0.108	0.619	0.538	6	27	81.8	0.062	0.803	7	26	78.8	1.348	0.246	12	21	63.6	0.217	0.642
< 60	29	0.892 ± 0.132			6	23	79.3			3	26	89.7			8	21	72.4
Histologic grading
I	15	0.795 ± 0.056			7	8	53.3			7	8	53.3			8	7	46.7
II	25	0.898 ± 0.086	22.535	0.000	3	22	88.0	9.520	0.009	2	23	92.0	13.744	0.001	7	18	72.0	4.014	0.134
III	22	0.979 ± 0.128			2	20	90.9			1	21	95.5			5	17	77.3
Invasion depth
Shallow group	7	0.751 ± 0.036			4	3	42.9			4	3	42.9			6	1	14.3
Deep group	55	0.924 ± 0.111	8.716	0.000	8	47	85.5	7.219	0.007	6	49	89.1	9.812	0.002	14	41	74.5	10.319	0.001
Lymphatic metastasis
Without	42	0.840 ± 0.074	9.042	0.000	11	31	73.8	3.898	0.048	10	32	76.2	5.678	0.017	18	24	57.1	6.693	0.010
With	20	1.032 ± 0.086			1	19	95.0			0	20	100.0			2	18	90.0

RhoC: Ras homolog C; VEGF: Vascular endothelial growth factor.