Microscopic colitis: A review of etiology, treatment and refractory disease

Table 3 Response rate to immunomodulators and anti-tumor necrosis factor for severe or refractory microscopic colitis

	Number of patients	Mean age (yr)	Treatment	Duration of therapy	Response rate
Münch et al[22], 2013	46	59	Azathioprine or 6-MP 2 mg/kg per day	Variable, 1-57 mo	41%
Pardi et al[30], 2001	9	62	Azathioprine or 6-MP 2 mg/kg per day	26 mo	56%
Münch et al[21], 2013	9	62	Methotrexate 15-25 mg/wk	12 wk	0%
Esteve et al[25], 2011	4	59	Infliximab 5 mg/kg at 0, 2, 6 wk then every 6-8 wk intravenously	Variable, 5-14 mo	75%
Münch et al[26], 2012	3	55	Adalimumab induction1 then 40 mg subcutaneously every 2 wk	6 wk	66%
Pola et al[24], 2013	1	58	Infliximab 5 mg/kg at 0, 2, 6 wk then every 8 wk intravenously	6 mo	100%

¹Adalimumab induction: 160 mg (week 0), 80 mg (week 2), and 40 mg (week 4).