TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity

Figure 8 Inhibition of nuclear factor-κB attenuates visceral hypersensitivity. A: PDTC treatment greatly increased the distention threshold in NCI rats (n = 6 for each group, ^aP < 0.05, vs NS); B: PDTC significantly reduced the abdominal withdrawal reflex (AWR) scores of NCI rats (n = 6 for each group, ^aP < 0.05, vs NS).