TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity

Figure 5 Inhibition of toll-like receptor 4 suppresses cystathionine β synthetase expression in neonatal colonic inflammation rats. A: Immunofluorescence analysis of TLR4 expression in CBS-positive, colon-specific DRG neurons; B: Western blotting analysis for CBS after CLI095 treatment in NCI rats. Normal saline was used as a control. n = 6 for each group, ^aP < 0.05, vs NS. Bar = 50 μm. TLR4: Toll-like receptor 4; CBS: Cystathionine β synthetase.