Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice

Figure 2 Body weight change in colitis model induced by piroxicam treatment. Interleukin (IL)-10^-/- mice (stress positive, n = 4; stress negative, n = 6) were exposed to restraint stress for 2 h per day for 3 consecutive days. IL-10^-/- mice were then treated with piroxicam for 4 d at a dose of 200 ppm in the rodent chow. Body weight was evaluated daily and mice were sacrificed on the 7^th day after the first exposure to restraint stress. Body weight was significantly reduced in IL-10^-/- mice exposed to restraint stress 5 d after administration of piroxicam. ^aP < 0.05 vs stress negative IL-10^-/- mice.