Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn’s disease

Table 3 Univariate and multivariate meta-regression analyses of potential sources of heterogeneity

Heterogeneity factors	Coefficient	SE	Z	Pvalue	95%CI
					LL	UL
Publication year
Univariate	0.004	0.036	0.12	0.908	-0.066	0.075
Multivariate	-0.052	0.038	-1.39	0.166	-0.126	0.022
SNP type
Univariate	-0.188	0.084	-2.25	0.025	-0.353	-0.024
Multivariate	-0.077	0.091	-0.84	0.398	-0.256	0.102
Ethnicity
Univariate	0.241	0.095	2.55	0.011	0.056	0.427
Multivariate	0.476	0.250	1.90	0.057	-0.014	0.967
Genotyping method
Univariate	-0.082	0.066	-1.25	0.211	-0.211	0.047
Multivariate	0.075	0.082	0.92	0.360	-0.085	0.235
Sample size
Univariate	0.194	0.148	1.31	0.190	-0.096	0.485
Multivariate	-0.216	0.244	-0.89	0.376	-0.696	0.263

SE: Standard error; SNP: Single nucleotide polymorphism; UL: Upper limit; LL: Lower limit.