Aggressive surgical resection does not improve survival in operable esophageal squamous cell carcinoma with N2-3 status

Table 3 Influence of combined therapy on survival for patients with N0, N1, or N2-3 status

Factors	Surgery alone	Combined therapy
In patients with N0 status (n = 727)
No. at risk	644	83
No. of events	275	35
uHR (95%CI)	1	0.878 (0.617-1.249)
P value1		0.469
In patients with N1 status (n = 419)
No. at risk	313	106
No. of events	217	63
aHR (95%CI)	1	0.712 (0.537-0.944)
P value2		0.018
In patients with N2-3 status (n = 344)
No. at risk	214	130
No. of events	169	100
aHR (95%CI)	1	0.672 (0.521-0.867)
P value3		0.002

¹Univariate analysis;

²Multivariate analysis adjusted for sex (male/female), age (≤ 58/> 58 years), tumor location (upper/mid/lower), pathologic T status (T1/T2/T3/T4a), and tumor cell differentiation (well/moderate/poor);

³Multivariate analysis adjusted for sex, age, tumor location, pathologic T status, nodal status (N2/N3), and tumor cell differentiation. aHR: Adjusted hazard ratio; uHR: Unadjusted hazard ratio.