Clinical characteristics of Helicobacter pylori-negative drug-negative peptic ulcer bleeding

Table 4 Univariate and multivariate analysis between drug-induced and Helicobacter pylori-associated peptic ulcer bleeding

	Drug-induced PUB (n = 74)	Helicobacter pylori-associated PUB (n = 108)	P value1	OR (95%CI)1	P value2	OR (95%CI)2
Age			< 0.01	7.71 (3.95-15.07)	< 0.01	4.51 (1.83-11.11)
≥ 60 yr	54	28
< 60 yr	20	80
Sex			< 0.01	0.21 (0.11-0.42)	0.03	0.39 (0.17-0.91)
Male	37	89
Female	37	19
Ulcer type			< 0.01	3.48 (1.80-6.73)	< 0.01	4.09 (1.73-9.64)
Gastric ulcer	57	53
Others	17	55
Ulcer size			0.03	1.95 (1.07-3.57)	0.62	0.82 (0.37-1.81)
≥ 1.0 cm	39	40
< 1.0 cm	35	68
Creatinine			0.61	0.85 (0.47-1.55)	0.11	0.52 (0.23-1.16)
≥ 1.0 mg/dL	41	64
< 1.0 mg/dL	33	44
Duration of admission			< 0.01	2.71 (1.45-5.07)	0.04	2.28 (1.04-5.00)
≥ 7 d	36	28
< 7 d	38	80
Needs for transfusion			0.43	1.28 (0.70-2.34)	0.62	1.23 (0.55-2.76)
≥ 3 PRCs	31	39
< 3 PRCs	43	69
Blatchford score			0.02	2.15 (1.16-3.96)	0.2	1.70 (0.76-3.82)
≥ 10 points	48	51
< 10 points	26	57
Rockall score			< 0.01	3.94 (2.09-7.43)	0.49	1.35 (0.58-3.13)
≥ 4 points	51	40
< 4 points	23	68

¹P value and OR (95%CI) by univariate logistic regression analysis;

²P value and OR (95%CI) by multivariate logistic regression analysis. PUB: Peptic ulcer bleeding; PRC: Packed red cell.