Clinical characteristics of Helicobacter pylori-negative drug-negative peptic ulcer bleeding

Table 1 Clinical characteristics and outcomes of patients with peptic ulcer bleeding

Etiology of PUB	Idiopathic (n = 20)	H. pylori-associated (n = 108)	Drug-induced (n = 74)	Combined (H. pylori, Drug) (n = 30)	P value	P value1	P value2	P value3
Age	55.15 ± 12.33	47.83 ± 15.15	68.49 ± 14.76	63.87 ± 14.79	< 0.01	0.09	< 0.01	0.09
Sex (M:F)	19:1	89:19	37:37	17:13	< 0.01	0.24	< 0.01	< 0.01
Smoking (Yes:No)	10:10	53:55	21:53	7:23	< 0.01	1	0.12	0.10
Alcohol (Yes:No)	6:14	27:81	14:60	5:25	0.554	0.85	0.364	0.314
Gastric ulcer (GU)	12	53	57	21	< 0.01	0.644	0.044	0.084
Duodenal ulcer (DU)	6	44	6	2
GU + DU	2	11	11	7
Initial hemoglobin (g/dL)	9.98 ± 3.15	9.36 ± 2.56	8.75 ± 2.73	8.84 ± 2.39	0.19	0.57	0.14	0.26
Creatinine (mg/dL)	1.040 ± 0.179	1.018 ± 0.435	1.255 ± 0.845	1.03 ± 0.356	0.05	0.99	0.27	1.00
Duration of admission (d)	6.15 ± 2.277	5.602 ± 2.411	8.473 ± 8.919	5.5 ± 2.556	< 0.01	0.93	0.18	0.93
Ulcer size (cm)	1.21 ± 0.65	0.86 ± 0.51	1.25 ± 0.92	1.07 ± 0.80	< 0.01	0.12	0.99	0.80
Needs for transfusion(PRC no.)	2.35 ± 2.46	2.21 ± 1.98	3.53 ± 4.94	2.53 ± 1.74	0.06	0.99	0.29	0.99
Re-bleeding caseupon admission:	6	8	2	2	< 0.014	< 0.014	< 0.014	< 0.054
Re-admission	2	3	4	2	0.304	0.174	0.604	14
Past history of ulcer	6	25	2	8	< 0.014	0.574	< 0.014	1
Blatchford score	8.85 ± 4.06	8.56 ± 3.71	9.78 ± 3.77	10.40 ± 3.94	0.05	0.97	0.56	0.29
Rockall score	3.50 ± 1.05	3.05 ± 1.54	4.73 ± 2.21	4.73 ± 1.87	< 0.01	0.52	0.02	0.04

P value by 1-way ANOVA.

¹P value by post-hoc test (Dunnett test between Idiopathic and H. pylori-associated);

²P value by post-hoc test (Dunnett test between Idiopathic and Drug-induced);

³P value by post-hoc test (Dunnett test between Idiopathic and Combined);

⁴P value by Fisher’s exact test values shown as mean ± SD. PUB: Peptic ulcer bleeding; PRC: Packed red cell; H. pylori: Helicobacter pylori.