Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B

Table 3 Association tests of PNPLA3 single nucleotide polymorphisms with histological features in chronic hepatitis B + nonalcoholic fatty liver disease patients

Condition	PNPLA3 genotype			P value
	CC (n = 12)	CG (n = 27)	GG (n = 18)
Steatosis	rs738409: CC	rs738409: CG	rs738409: GG	rs738409: 0.384;
	M: ≤ 1: 5 (41.67%);	M: ≤ 1: 11 (40.74%);	M: ≤ 1: 4 (22.22%);	rs3747206: 0.384;
	F: > 1: 7 (58.33%)	F: > 1: 16 (59.26%)	F: > 1: 14 (77.73%)	rs4823173: 0.374;
	rs3747206: CC	rs3747206: CT	rs3747206: TT	rs2072906: 0.275
	M: ≤ 1: 5 (41.67%);	M: ≤ 1: 11 (40.74%);	M: ≤ 1: 4 (22.22%);
	F: > 1: 7 (58.33%)	F: > 1: 16 (59.26%)	F: > 1: 14 (77.73%)
	rs4823173: GG	rs4823173: GA	rs4823173: AA
	M: ≤ 1: 5 (38.46%);	M: ≤ 1: 11 (42.31%);	M: ≤ 1: 4 (22.22%);
	F: > 1: 8 (61.54%)	F: > 1: 15 (57.69%)	F: > 1: 14 (77.73%)
	rs2072906: AA	rs2072906: AG	rs2072906: GG
	M: ≤ 1: 5 (38.46%);	M: ≤ 1: 11 (44.00%);	M: ≤ 1: 4 (21.05%);
	F: >1: 8 (61.54%)	F: > 1: 14 (56.00%)	F: > 1: 15 (78.95%)
Lobular inflammation	rs738409: CC	rs738409: CG	rs738409: GG	rs738409: 0.706;
	M: ≤ 1: 5 (41.67%);	M: ≤ 1: 10 (37.04%);	M: ≤ 1: 5 (27.78%);	rs3747206: 0.706;
	F: > 1: 7 (58.33%)	F: > 1: 17 (62.96%)	F: > 1: 13 (72.22%)	rs4823173: 0.570;
	rs3747206: CC	rs3747206: CT	rs3747206: TT	rs2072906: 0.509
	M: ≤ 1: 5 (41.67%);	M: ≤ 1: 10 (37.04%);	M: ≤ 1: 5 (27.78%);
	F: > 1: 7 (58.33%)	F: > 1: 17 (62.96%)	F: > 1: 13 (72.22%)
	rs4823173: GG	rs4823173: GA	rs4823173: AA
	M: ≤ 1: 6 (46.15%);	M: ≤ 1: 9 (34.62%);	M: ≤ 1: 5 (27.78%);
	F: > 1: 7 (53.85%)	F: > 1: 17 (65.38%)	F: > 1: 13 (72.22%)
	rs2072906: AA	rs2072906: AG	rs2072906: GG
	M: ≤ 1: 6 (46.15%);	M: ≤ 1: 9 (36.00%);	M: ≤ 1: 5 (26.32%);
	F: > 1: 7 (53.85%)	F: > 1: 16 (64.00%)	F: > 1: 14 (73.68%)
Ballooning	rs738409: CC	rs738409: CG	rs738409: GG	rs738409: 0.021
	M: ≤ 1: 6 (50.0%);	M: ≤ 1: 9 (33.33%);	M: ≤ 1: 1 (5.56%);	(CC vs GG: P = 0.005; CG vs GG: P = 0.028);
	F: > 1: 6 (50.0%)	F: > 1: 18 (66.67%)	F: > 1: 17 (94.44%)	rs3747206: 0.021
	rs3747206: CC	rs3747206: CT	rs3747206: TT	(CC vs TT: P = 0.005; CT vs TT: P = 0.028);
	M: ≤ 1: 6 (50.00%);	M: ≤ 1: 9 (33.33%);	M: ≤ 1: 1 (5.56%);	rs4823173: 0.012
	F: > 1: 6 (50.00%)	F: > 1: 18 (66.67%)	F: > 1: 17 (94.44%)	(GG vs AA: P = 0.002; GA vs AA: P = 0.041);
	rs4823173: GG	rs4823173: GA	rs4823173: AA	rs2072906: 0.009
	M: ≤ 1: 7 (53.85%);	M: ≤ 1: 8 (30.77%);	M: ≤ 1: 1 (5.56%);	(AA vs GG: P = 0.002; AG vs GG: P = 0.029)
	F: > 1: 6 (46.15%)	F: > 1: 18 (69.23%)	F: > 1: 17 (94.44%)
	rs2072906: AA	rs2072906: AG	rs2072906: GG
	M: ≤ 1: 7 (53.85%);	M: ≤ 1: 8 (32.0%);	M: ≤ 1: 1 (5.26%);
	F: > 1: 6 (46.15%)	F: > 1: 17 (68.0%)	F: > 1: 18 (94.74%)
NAS	rs738409: CC	rs738409: CG	rs738409: GG	rs738409: 0.039
	M: < 3: 10 (83.33%);	M: < 3: 11 (40.74%);	M: < 3: 8 (44.44%);	(CC vs CG: P = 0.014; CC vs GG: P = 0.033);
	F: ≥ 3: 2 (16.67%)	F: ≥ 3: 16 (59.26%)	F: ≥ 3: 10 (55.56%)	rs3747206: 0.039
	rs3747206: CC	rs3747206: CT	rs3747206: TT	(CC vs CG: P = 0.014; CC vs GG: P = 0.033);
	M: < 3: 10 (83.33%);	M: < 3: 11 (40.74%);	M: < 3: 8 (44.44%);	rs4823173: 0.020
	F: ≥ 3: 2 (16.67%)	F: ≥ 3: 16 (59.26%)	F: ≥ 3: 10 (55.56%)	(GG vs GA: P = 0.006; GG vs AA: P = 0.023);
	rs4823173: GG	rs4823173: GA	rs4823173: AA	rs2072906: 0.021
	M: < 3: 11 (84.62%);	M: < 3: 10 (38.46%);	M: < 3: 8 (44.44%);	(AA vs AG: P = 0.009; AA vs GG: P = 0.016)
	F: ≥ 3: 2 (15.38%)	F: ≥ 3: 16 (61.54%)	F: ≥ 3: 10 (55.56%)
	rs2072906: AA	rs2072906: AG	rs2072906: GG
	M: < 3: 11 (84.62%);	M: < 3: 10 (40.0%);	M: < 3: 8 (42.11%);
	F: ≥ 3: 2 (15.38%)	F: ≥ 3: 15 (60.0%)	F: ≥3: 11 (57.89%)
Fibrosis grading	rs738409: CC	rs738409: CG	rs738409: GG	rs738409: 0.032
	M: ≤ 1: 11 (91.67%);	M: ≤ 1: 17 (62.96%);	M: ≤ 1: 8 (44.44%);	(CC vs GG: P = 0.009);
	F: > 1: 1 (8.33%)	F: > 1: 10 (37.04%)	F: > 1: 10 (55.56%)	rs3747206: 0.032
	rs3747206: CC	rs3747206: CT	rs3747206: TT	(CC vs TT: P= 0.009);
	M: ≤ 1: 11 (91.67%);	M: ≤ 1: 17 (62.96%);	M: ≤ 1: 8 (44.44%);	rs4823173: 0.024
	F: > 1: 1 (8.33%)	F: > 1: 10 (37.04%)	F: > 1: 10 (55.56%)	(GG vs GA: P = 0.044; GG vs AA: P = 0.006);
	rs4823173: GG	rs4823173: GA	rs4823173: AA	rs2072906: 0.015
	M: ≤ 1: 12 (92.31%);	M: ≤ 1: 16 (61.54%);	M: ≤ 1: 8 (44.44%);	(AA vs GG: P = 0.004)
	F: > 1: 1 (7.69%)	F: > 1: 10 (38.46%)	F: > 1: 10 (55.56%)
	rs2072906: AA	rs2072906: AG	rs2072906: GG
	M: ≤ 1: 12 (92.31%);	M: ≤ 1: 16 (64.0%);	M: ≤ 1: 8 (42.11%);
	F: > 1: 1 (7.69%)	F: > 1: 9 (36.0%)	F: > 1: 11 (57.89%)

NAS: Nonalcoholic fatty liver disease activity score.