Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B

doi:10.3748/wjg.v21.i28.8605

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World Journal of Gastroenterology

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World J Gastroenterol. Jul 28, 2015; 21(28): 8605-8614
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8605

Table 2 Association tests of PNPLA3 single nucleotide polymorphisms

Groups	SNPs	Group (%)			OR (95%CI)			P value
Groups	SNPs	Normal	CHB	CHB + NAFLD	Unadjusted	Adjusted for age, sex	Adjusted for age, sex, and BMI	Unadjusted	Adjusted for age and sex	Adjusted for age, sex, and BMI
CHB+NAFLD vs CHB	738409		C: 57.84G: 42.16	C: 44.74G: 55.26	1.695(0.989-2.906)	2.334(1.169-4.657)	2.774(1.176-6.543)	0.054	0.016	0.020
	3747206		C: 57.84T: 42.16	C: 44.74T: 55.26	1.695(0.989-2.906)	2.334(1.169-4.657)	2.774(1.176-6.543)	0.054	0.016	0.020
	4823173		G: 58.82A: 41.18	G: 45.61A: 54.39	1.703(0.993-2.922)	2.134(1.089-4.180)	2.734(1.161-6.437)	0.052	0.027	0.021
	2072906		A: 58.82G: 41.18	C: 44.74G: 55.26	1.765 (1.028-3.029)	2.314(1.174-4.559)	3.045(1.277-7.262)	0.039	0.015	0.012
CHB+NAFLD vs normal	738409	C: 63.83G: 36.17		C: 44.74G: 55.26	2.180(1.246-3.815)	2.529(1.335-4.792)	3.018(1.318-6.914)	0.00	0.004	0.009
	3747206	C: 63.83G: 36.17		C: 44.74T: 55.26	2.180(1.246-3.815)	2.529(1.335-4.792)	3.018(1.318-6.914)	0.006	0.004	0.009
	4823173	C: 63.83G: 36.17		G: 45.61A: 54.39	2.104(1.203-3.681)	2.536(1.329-4.840)	3.212(1.344-7.679)	0.009	0.005	0.009
	2072906	C: 63.83G: 36.17		C: 44.74G: 55.26	2.180(1.246-3.815)	2.684(1.403-5.134)	3.499(1.452-8.430)	0.006	0.003	0.005
CHB vs normal	738409	C: 63.83G: 36.17	C: 57.84G: 42.16		1.286( 0.723-2.287)	1.356(0.695-2.643)	1.315(0.674-2.567)	0.391	0.372	0.422
	3747206	C: 63.83G: 36.17	C: 57.84T: 42.16		1.286(0.723-2.287)	1.356(0.695-2.643)	1.315(0.674-2.567)	0.391	0.372	0.422
	4823173	C: 63.83G: 36.17	G: 58.82A: 41.18		1.235(0.694-2.199)	1.439(0.717-2.889)	1.325(0.652-2.694)	0.472	0.306	0.437
	2072906	C: 63.83G: 36.17	G: 58.82A: 41.18		1.235(0.694-2.199)	1.439(0.717-2.889)	1.325(0.652-2.694)	0.472	0.306	0.437

BMI: Body mass index; CHB: Chronic hepatitis B; CI: Confidence interval; NAFLD: Nonalcoholic fatty liver disease; OR: Odds ratio; SNPs: Single nucleotide polymorphisms.

Citation: Pan Q, Zhang RN, Wang YQ, Zheng RD, Mi YQ, Liu WB, Shen F, Chen GY, Lu JF, Zhu CY, Zhang SY, Chen YM, Sun WL, Fan JG. Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B. World J Gastroenterol 2015; 21(28): 8605-8614
URL: https://www.wjgnet.com/1007-9327/full/v21/i28/8605.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i28.8605