Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B

Table 1 Demographic and clinical data of all patients

Variable	Normal group (n = 47)	CHB group (n = 51)	CHB + NAFLD group (n = 57)	P value
Age (yr)	46.74 ± 6.97	36.76 ± 12.60	38.98 ± 13.55	< 0.001
Sex, n (%)	M: 29 (61.70)	M: 34 (66.67)	M: 42 (73.68)	0.420
	F: 18 (38.30)	F: 17 (33.33)	F: 15 (26.32)
BMI (kg/m2)	23.43 ± 2.59	22.84 ± 2.97	27.40 ± 3.24	< 0.001
TC (mmol/L)	4.40 ± 1.22	4.39 ± 0.96	4.89 ± 0.84	0.023
TG (mmol/L)	0.98 ± 0.31	1.12 ± 0.38	1.84 ± 1.35	< 0.001
HDL (mmol/L)	1.51 ± 1.22	1.50 ± 0.44	1.20 ± 0.28	0.142
LDL (mmol/L)	2.03 ± 0.85	2.22 ± 0.56	2.94 ± 1.02	< 0.001
FBG (mmol/L)	3.39 ± 1.30	4.11 ± 0.63	5.71 ± 1.92	< 0.001
ALT (U/L)	13. 72 ± 4.16	76.14 ± 53.70	68.51 ± 47.20	< 0.001
TBIL (μmol/L)	2.25 ± 0.51	23.78 ± 21.44	5.80 ± 3.55	< 0.001
GGT (U/L)	16.42 ± 7.31	94.33 ± 94.13	60.18 ± 36.81	< 0.001
ALP (U/L)	16.08 ± 5.48	95.23 ± 40.35	101.16 ± 88.46	< 0.001

CHB: Chronic hepatitis B; NAFLD: Nonalcoholic fatty liver disease; BMI: Body mass index; TC: Total cholesterol; TG: Triglyceride; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; FBG: Fasting blood glucose; ALT: Alanine aminotransferase; TBIL: Total bilirubin; GGT: γ-glutamyltransferase; ALP: Alkaline phosphatase.