Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma

Table 3 Prognostic factors for the 3-year survival rate by univariate and Cox proportional multivariate analysis

Factor		Univariate analysis		Multivariate analysis
		3-year survival rate(%)	P value	HR (95%CI)	P value
Gender	Female/male	70.7/71.2	0.921
Age (yr)	< 60/≥ 60	69.5/72.6	0.518
Hepatitis type	HBV/HCV/none	73.0/83.3/52.7	0.265
Cirrhosis	Present/none	74.8/59.9	0.051
TNM stage	I/II/III	83.6/48.6/52.7	< 0.001	0.254 (0.097-0.660)	0.005
				1.238 (0.465-3.295)	0.670
Histological type	Well/moderately/poorlydifferentiated	83.2/67.1/66.2	0.059
Macrovascular invasion	Present/none	60.0/71.8	0.008	1.623 (0.203-13.002)	0.648
Microvascular invasion	Present/none	47.6/78.9	0.011	0.834 (0.358-1.939)	0.673
Tumor size (cm)	≥ 5/< 5	58.6/80.2	0.005	1.488 (0.680-3.255)	0.319
Serum AFP level (ng/mL)	≥ 400/< 400	59.5/77.6	0.013	1.181 (0.494-2.2820)	0.708
LiverEncapsulation invasion	Present/none	18.2/76.5	< 0.001	2.282 (0.340-15.307)	0.395
Tumor number	Solitary/multiple	74.4/57.1	0.125
Surgical intervention	Radical resection/palliative resection	78.0/39.5	< 0.001	0.811 (0.138-4.754)	0.817
Postoperative TACE	Yes/no	77.0/48.5	< 0.001	0.192 (2.157-9.159)	<0.001
CCT3 expression in cytoplasm	Positive/negative	66.8/82.2	0.185
CCT3 expression in nucleus	Positive/negative	55.5/84.2	0.015	2.387 (1.144-4.981)	0.020
Child-Pugh classification	A/B	71.7/66.7	0.496

TACE: Transcatheter arterial chemoembolization.