Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma

Table 2 Associations between subunit 3 expression in different subcellular localizations in cancerous cells and clinicopathological variables of patients with hepatocellular carcinoma n (%)

Feature	n	CCT3 expression in cytoplasm		P value	CCT3 expression in nucleus		P value
		(+)	(-)		(+)	(-)
Gender (F/M)
Female	21	14 (18.7)	7 (24.1)		11 (19.0)	10 (21.7)
Male	83	61 (81.3)	22 (75.9)	0.533	47 (81.0)	36 (78.3)	0.726
Age (yr)
< 60	56	39 (52.0)	17 (58.6)		31 (53.4)	25 (54.3)
≥ 60	48	36 (48.0)	12 (41.4)	0.544	27 (46.6)	21 (45.7)	0.927
Hepatitis type
HBV	85	59 (78.7)	26 (89.7)		49 (84.5)	36 (78.3)
HCV	6	4 (5.3)	2 (6.9)		2 (3.4)	4 (8.7)
None	13	12 (16.0)	1 (7.7)	0.190	7 (12.1)	6 (13.0)	0.581
Cirrhosis
Present	78	54 (72.0)	24 (82.8)		43 (74.1)	35 (76.1)
None	26	21 (28.0)	5 (17.2)	0.2561	5 (25.9)	11 (23.9)	0.820
UICC stage
I	64	46 (61.3)	18 (62.1)		31 (53.4)	33 (71.7)
II	12	11 (14.7)	1 (3.4)	0.208	10 (17.2)	2 (4.3)	0.068
IIIA	28	18 (24.0)	10 (34.5)		17 (29.3)	11 (23.9)
Histological type
Well-differentiated	26	16 (21.3)	10 (34.5)		5 (8.6)	21 (45.7)
Moderately-differentiated	60	45 (60.0)	15 (51.7)		36 (62.1)	24 (52.2)
Poorly-differentiated	18	14 (18.7)	4 (13.8)	0.371	17 (29.3)	1 (2.2)	< 0.001
Macrovascular invasion
None	99	71 (94.7)	28 (96.6)		54 (93.1)	45 (97.8)
Present	5	4 (5.3)	1 (3.4)	1.000	4 (6.9)	1 (2.2)	0.380
Microvascular invasion
None	78	55 (73.3)	23 (79.3)		39 (67.2)	39 (84.8)
Present	26	20 (26.7)	6 (20.7)	0.528	19 (32.8)	7 (15.2)	0.040
Tumor size (cm)
≥ 5	46	35 (46.7)	11 (37.9)		28 (48.1)	18 (62.9)
< 5	58	40 (53.3)	18 (62.1)	0.421	30 (51.9)	28 (37.1)	0.351
Serum AFP level (ng/mL)
< 400	79	56 (74.7)	23 (79.3)		43 (74.1)	36 (78.3)
≥ 400	25	19 (25.3)	6 (20.7)	0. 619	15 (25.9)	10 (21.7)	0.625
Tumor number
Solitary	83	62 (82.7)	21 (72.4)		46 (79.3)	37 (80.4)
Multiple	21	13 (17.3)	8 (27.6)	0.243	12 (20.7)	9 (19.6)	0.887
Liver encapsulation invasion
None	93	66 (88.0)	27 (93.1)		52 (89.7)	41 (89.1)
Present	11	9 (12.0)	2 (6.9)	0.687	6 (10.3)	5 (10.9)	1.000

HBV: Hepatitis B virus; HCV: Hepatitis C virus.