Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice

Figure 5 Effect of Clostridium butyricum on the levels of IL-1β, TNF-α and LTB4 in the gastric mucosa of mice with gastric ulcers induced by alcohol, cold stress or pylorus ligation. Gastric ulcer models were induced by alcohol (A-C), cold stress (D-F) or pylorus ligation (G-I), respectively. The levels of IL-1β (A, D, G), TNF-α (B, E, H) and LTB4 (C, F, I) in gastric tissue of different GU mice were quantified. For each GU model, there were four different groups: Sham control group (1), Model group (without pretreatment) (2), Clostridium butyricum (C. butyricum) pretreatment group (3) and Omeprazole pretreatment group (4). The data were expressed as mean ± SD (n = 6). ^aP < 0.01 vs Model group; ^bP < 0.01 vs Omeprazole group; ^cP < 0.01 vs Sham control group.