Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B

Table 3 Regression coefficients and integer risk scores of acute-on-chronic liver failure predictors estimated from the derivation set

ACLF predictors	Regression coefficient	P value	Risk score
Age ≥ 40 (yr)	1.128	0.010	1
TBil ≥ 171 (μmol/L)	1.237	0.007	1
PTA (%)
50.1-60	2.158	0.001	2
40-50	2.868	< 0.001	3
HBV DNA > 107 (copies/mL)	1.946	< 0.001	2
Overall risk level	ACLF rate		Total score
Low risk	0%-4.7%		0-3
High risk	26.0%-68.8%		4-7

The regression coefficient 1.128 is considered as one risk point. ACLF: Acute-on-chronic liver failure; HBV: Hepatitis V virus; PTA: Prothrombin activity; TBil: Total bilirubin.