TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury

doi:10.3748/wjg.v21.i27.8314

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2015; 21(27): 8314-8325
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8314

Table 2 Concentrations of inflammatory factors in serum (mean ± SD)

Group(n = 8)	p65 (pg/mL)	IL-6 (pg/mL)	TNF-α(pg/mL)
Sham	104.64 ± 11.89	50.02 ± 6.33	43.79 ± 4.18
Control	228.53 ± 24.85^a	104.91 ± 31.18^a	70.81 ± 6.97^a
Anti-HMGB1	145.00 ± 33.63^a^b	62.28 ± 6.73^a^b	52.76 ± 5.71^a^b
Anti-MyD88	191.12 ± 13.22^a^b^c	85.90 ± 17.37^a^b^c	63.19 ± 5.47^a^b^c
Anti-TRIF	183.73 ± 10.81^a^b^c	78.14 ± 7.38^a^b^c	59.70 ± 4.63^a^b^c

^aP < 0.05 vs sham group;

^bP < 0.05 vs control group;

^cP < 0.05 vs anti-HMGB1 group. HMGBI: High-mobility group protein 1; IL: Interleukin; MyD88: Myeloid differentiation gene 88; TNF-α: Tumor necrosis factor-α; TRIF: Translocating-chain-associating membrane protein.

Citation: Wang J, He GZ, Wang YK, Zhu QK, Chen W, Guo T. TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury. World J Gastroenterol 2015; 21(27): 8314-8325
URL: https://www.wjgnet.com/1007-9327/full/v21/i27/8314.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i27.8314