Copyright
©The Author(s) 2015.
World J Gastroenterol. Jul 21, 2015; 21(27): 8284-8292
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8284
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8284
Table 3 Summary of miRNA and chemosensitivity
| miRNA and chemosensitivity | Summary | |
| Micro RNA | Ref. | |
| miR-21 | [65-68] | Increased expression causes decreased chemosensitivity |
| miR-153 | [69] | Up regulation, increased resistance to oxaliplatin and cisplatin |
| miR-19a | [70] | Up regulation leads to resistance of FOLFOX therapy |
| miR-106a | [71] | Up regulation leads to resistance of 5-FU and oxalilatin |
| miR-130b | [71] | Up regulation leads to resistance of 5-FU and oxalilatin |
| miR-484 | [71] | Up regulation leads to resistance of 5-FU and oxalilatin |
| miR-129 | [72] | Down regulation increases resistance to 5-FU, transfection of miRNA into existing cells increase cytotoxic effect 5-FU |
| miR-15b | [73] | Down regulation increases resistance to 5-FU |
| miR-1915 | [74] | Down regulation decreases chemotherapy by modulating apoptotic pathway |
| miR-122 | [75] | Down regulation increases resistant to 5-FU |
- Citation: Hollis M, Nair K, Vyas A, Chaturvedi LS, Gambhir S, Vyas D. MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity. World J Gastroenterol 2015; 21(27): 8284-8292
- URL: https://www.wjgnet.com/1007-9327/full/v21/i27/8284.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i27.8284