Editorial
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 21, 2015; 21(27): 8221-8226
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8221
Table 1 Non-celiac gluten sensitivity identikit
Name and definitionPathogenesisPrevalenceDiagnosisTreatment
Non-celiac gluten/wheat sensitivity is an intestinal/extraintestinal syndrome responsive to gluten withdrawal in absence of CD and WAMulti-factorial, including innate immunity and direct cytotoxic effects of glutenRanging from 3% to 5%, though specific studies are lackingVia placebo-controlled blind gluten challengeNo data are available for guidance
Other molecules are potentially involved: Amylase trypsin inhibitor, FODMAPsPrior exclusion of celiac disease and allergyAn on-demand gluten-free regimen should be considered
AGA IgG, IELs, basophil activation and eosinophil duodenal/colon infiltration are potential biomarkers