Copyright
©The Author(s) 2015.
World J Gastroenterol. Jul 21, 2015; 21(27): 8221-8226
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8221
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8221
Name and definition | Pathogenesis | Prevalence | Diagnosis | Treatment |
Non-celiac gluten/wheat sensitivity is an intestinal/extraintestinal syndrome responsive to gluten withdrawal in absence of CD and WA | Multi-factorial, including innate immunity and direct cytotoxic effects of gluten | Ranging from 3% to 5%, though specific studies are lacking | Via placebo-controlled blind gluten challenge | No data are available for guidance |
Other molecules are potentially involved: Amylase trypsin inhibitor, FODMAPs | Prior exclusion of celiac disease and allergy | An on-demand gluten-free regimen should be considered | ||
AGA IgG, IELs, basophil activation and eosinophil duodenal/colon infiltration are potential biomarkers |
- Citation: Elli L, Roncoroni L, Bardella MT. Non-celiac gluten sensitivity: Time for sifting the grain. World J Gastroenterol 2015; 21(27): 8221-8226
- URL: https://www.wjgnet.com/1007-9327/full/v21/i27/8221.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i27.8221