Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation

Figure 3 Role of losartan pretreatment in endoplasmic reticulum stress parameters. A: GRP78; B: IRE1α; C: p-eIF2 protein levels. ^aP < 0.05 vs Sham, ^bP < 0.05 vs ROLT. Sham: Liver harvested without transplantation; ROLT: Liver subjected to reduced-size orthotopic liver transplantation after 1 h of cold storage in University of Wisconsin solution; losartan + ROLT: Same as ROLT group, but with further administration of losartan 24 h and 1 h before the surgical procedure to both the donor and the recipient.