Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation

Figure 2 Implication of losartan administration in mRNA (A) and protein levels of sirtuin 3 (B). ^aP < 0.05 vs Sham. Sham: Liver harvested without transplantation; ROLT: Liver subjected to reduced-size orthotopic liver transplantation after 1 h of cold storage in University of Wisconsin solution; losartan + ROLT: Same as ROLT group, but with further administration of losartan 24 h and 1 h before the surgical procedure to both the donor and the recipient.