Changes in gene expression in liver tissue from patients with fulminant hepatitis E

doi:10.3748/wjg.v21.i26.8032

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 14, 2015; 21(26): 8032-8042
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.8032

Table 2 Gene Ontology analysis (biological processes) for gene entities differentially expressed in liver tissue from fulminant hepatitis E as compared to normal liver tissue, as well as in fulminant hepatitis B as compared to normal liver tissue

Gene ontology accession	Gene Ontology term	P value
GO:0055114	Oxidation-reduction process	2.68E-40
GO:0006082	Organic acid metabolic process	4.75E-39
GO:0043436	Oxoacid metabolic process	2.17E-38
GO:0019752	Carboxylic acid metabolic process	4.09E-38
GO:0006629	Lipid metabolic process	3.94E-28
GO:0044281	Small molecule metabolic process	9.06E-27
GO:0032787	Monocarboxylic acid metabolic process	3.56E-22
GO:0016054	Organic acid catabolic process	4.22E-19
GO:0046395	Carboxylic acid catabolic process	4.22E-19
GO:0044255	Cellular lipid metabolic process	1.35E-17
GO:0044282	Small molecule catabolic process	5.16E-17
GO:0044712	Single-organism catabolic process	5.16E-17
GO:0006631	Fatty acid metabolic process	2.71E-16
GO:0006520	Cellular amino acid metabolic process	4.43E-16
GO:0044711	Single-organism biosynthetic process	8.25E-14
GO:1901605	Alpha-amino acid metabolic process	1.07E-13
GO:0044283	Small molecule biosynthetic process	1.60E-13
GO:1901564	Organonitrogen compound metabolic process	2.46E-11
GO:0009063	Cellular amino acid catabolic process	4.46E-11
GO:0008610	Lipid biosynthetic process	8.46E-11
GO:0072376	Protein activation cascade	3.87E-10
GO:0008202	Steroid metabolic process	4.10E-10
GO:0016053	Organic acid biosynthetic process	6.26E-10
GO:0046394	Carboxylic acid biosynthetic process	6.26E-10
GO:1901566	Organonitrogen compound biosynthetic process	1.94E-08
GO:0008152	Metabolic process	4.34E-08
GO:1901606	Alpha-amino acid catabolic process	4.58E-08
GO:0072329	Monocarboxylic acid catabolic process	1.40E-07
GO:0007596	Blood coagulation	1.98E-07
GO:0050817	Coagulation	1.98E-07
GO:0007599	Hemostasis	2.83E-07
GO:1901615	Organic hydroxy compound metabolic process	4.14E-07
GO:0042060	Wound healing	4.86E-07
GO:0006956	Complement activation	6.77E-07
GO:0009062	Fatty acid catabolic process	1.71E-06
GO:0006066	Alcohol metabolic process	1.82E-06
GO:0008652	Cellular amino acid biosynthetic process	2.42E-06
GO:0050878	Regulation of body fluid levels	5.46E-06
GO:0051186	Cofactor metabolic process	5.50E-06
GO:0006694	Steroid biosynthetic process	8.32E-06
GO:0044242	Cellular lipid catabolic process	1.09E-05
GO:0005996	Monosaccharide metabolic process	0.000012
GO:0051346	Negative regulation of hydrolase activity	1.28E-05
GO:0005975	Carbohydrate metabolic process	1.35E-05
GO:0010876	Lipid localization	5.30E-05
GO:0044710	Single-organism metabolic process	5.82E-05
GO:0006732	Coenzyme metabolic process	6.57E-05
GO:0010951	Negative regulation of endopeptidase activity	7.22E-05
GO:0019318	Hexose metabolic process	7.95E-05
GO:0006869	Lipid transport	8.02E-05
GO:0065008	Regulation of biological quality	8.96E-05
GO:0010466	Negative regulation of peptidase activity	0.0001
GO:0006006	Glucose metabolic process	0.0001
GO:0042558	Pteridine-containing compound metabolic process	0.0002
GO:0043648	Dicarboxylic acid metabolic process	0.0002
GO:0006958	Complement activation, classical pathway	0.0004
GO:0006091	Generation of precursor metabolites and energy	0.0004
GO:0044262	Cellular carbohydrate metabolic process	0.0004
GO:0006575	Cellular modified amino acid metabolic process	0.0005
GO:0016051	Carbohydrate biosynthetic process	0.0005
GO:0072330	Monocarboxylic acid biosynthetic process	0.0006
GO:0002455¹	Humoral immune response mediated by circulating immunoglobulin	0.0010
GO:0044723	Single-organism carbohydrate metabolic process	0.0010
GO:0019320	Hexose catabolic process	0.0011
GO:0016052	Carbohydrate catabolic process	0.0014
GO:0044724	Single-organism carbohydrate catabolic process	0.0014
GO:0006820	Anion transport	0.0016
GO:0006007	Glucose catabolic process	0.0017
GO:0046365	Monosaccharide catabolic process	0.0018
GO:0046835	Carbohydrate phosphorylation	0.0020
GO:1901617	Organic hydroxy compound biosynthetic process	0.0020
GO:0002253¹	Activation of immune response	0.0021
GO:0016125	Sterol metabolic process	0.0022
GO:0006096	Glycolysis	0.0023
GO:0019395	Fatty acid oxidation	0.0037
GO:0034440	Lipid oxidation	0.0037
GO:0046165	Alcohol biosynthetic process	0.0038
GO:0006959¹	Humoral immune response	0.0042
GO:0009611	Response to wounding	0.0044
GO:0006957	Complement activation, alternative pathway	0.0044
GO:0006760	Folic acid-containing compound metabolic process	0.0044
GO:0045087¹	Innate immune response	0.0053
GO:0052548	Regulation of endopeptidase activity	0.0077
GO:0046364	Monosaccharide biosynthetic process	0.0077
GO:0006790	Sulfur compound metabolic process	0.0078
GO:0051179	Localization	0.0079
GO:0052547	Regulation of peptidase activity	0.0083
GO:0046942	Carboxylic acid transport	0.0083
GO:0015849	Organic acid transport	0.0095
GO:0016042	Lipid catabolic process	0.0113
GO:0015711	Organic anion transport	0.0113
GO:0051234	Establishment of localization	0.0113
GO:0006810	Transport	0.0119
GO:0044092	Negative regulation of molecular function	0.0126
GO:0019319	Hexose biosynthetic process	0.0131
GO:0072378	Blood coagulation, fibrin clot formation	0.0132
GO:0006558	L-phenylalanine metabolic process	0.0146
GO:0006559	L-phenylalanine catabolic process	0.0146
GO:0000038	Very long-chain fatty acid metabolic process	0.0146
GO:0051289	Protein homotetramerization	0.0146
GO:0002252¹	Immune effector process	0.0153
GO:0008203	Cholesterol metabolic process	0.0153
GO:0009074	Aromatic amino acid family catabolic process	0.0212
GO:0048806	Genitalia development	0.0212
GO:0016064¹	Immunoglobulin mediated immune response	0.0214
GO:0050819	Negative regulation of coagulation	0.0214
GO:0043086	Negative regulation of catalytic activity	0.0224
GO:0034754	Cellular hormone metabolic process	0.0243
GO:0019724¹	B cell mediated immunity	0.0263
GO:0051262	Protein tetramerization	0.0279
GO:0050778¹	Positive regulation of immune response	0.0292
GO:0050776¹	Regulation of immune response	0.0341
GO:0006633	Fatty acid biosynthetic process	0.0372
GO:0003333	Amino acid transmembrane transport	0.0389
GO:0016126	Sterol biosynthetic process	0.0416
GO:0006811	Ion transport	0.0420
GO:0006094	Gluconeogenesis	0.0474
GO:0001676	Long-chain fatty acid metabolic process	0.0474

¹These pathways are related to immune responses.

Citation: Naik A, Goel A, Agrawal V, Sarangi AN, Chhavi N, Singh V, Jameel S, Aggarwal R. Changes in gene expression in liver tissue from patients with fulminant hepatitis E. World J Gastroenterol 2015; 21(26): 8032-8042
URL: https://www.wjgnet.com/1007-9327/full/v21/i26/8032.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i26.8032