Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

Figure 5 Effect of berberine on hepatic p-TORC2 and total TORC2 protein expression. Western blot analyses of p-TORC2 and TORC2 proteins from liver tissues of normal rats, model rats and diabetic rats treated with Berberine, AICAR and Metformin. A: Representative blots for each group are shown; B: Each bar is expressed as p-TORC2/β-actin and represents the mean ± SD (n = 8); C: Each bar is expressed as total TORC2/β-actin and represents the mean ± SD (n = 8). ^bP < 0.01 vs the normal group; ^dP < 0.01 vs the model group (by ANOVA).There was no significant difference in the expression of total TORC2 protein across the five groups.