Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats

Figure 3 Ezetimibe treatment attenuates triglycerides accumulation and induces autophagy in hepatocytes. Hepatic triglyceride concentration (A) and mRNA (B) and protein expression (C and D) involved in autophagy were expressed as the mean ± SE. Experiments represent at least three independent experiments (n≥ 9). ^aP < 0.05, ^bP < 0.01, vs control; ^cP < 0.05, ^dP < 0.01, PA vs PA + Ez. ATG: Autophagy-related gene; Con: Control; Ez: Ezetimibe; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; PA: Palmitic acid; TG: Triglycerides.