Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats

Figure 3 Representative photomicrographs of the pancreas in the four different treatment groups on day 12 after induction of acute pancreatitis. A: The pancreas of AP-C rat (ad libitum feeding with saline administration) showed destruction of pancreatic acini, tubular complexes and marked infiltration of inflammatory cells, mainly lymphocytes; B: The pancreas of AP-R rat (pancreatic rest) showed minimal histologic alterations with atrophic pancreatic acini and mild inflammatory cell infiltration; The pancreas in AP-S (C) (pancreatic stimulation) and AP-R/S rats (D) (pancreatic rest for the first 5 d followed by pancreatic stimulation for 5 d) showed almost normal architecture. Original magnification × 25. AP: Acute pancreatitis.