TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer

Figure 2 Toll-like receptor 2 and toll-like receptor 4 protein expression in intestinal mucosa (cytoplasm staining). Moderate expression of TLR2 in normal adjacent mucosa (NT), predominantly in epithelial cells (arrowhead) (A); compared with intense immunostaining in colorectal cancer (B); Low expression of TLR4 in normal adjacent mucosa, predominantly in the epithelium (arrowhead) (D); Moderate TLR4 immunostaining in the epithelial cells (arrowhead) of colorectal cancer (E); Harris’ Hematoxylin counterstain. Bar: 20 μm. Densitometry analyses (mean ± SE) (C and F); P < 0.001. All images are from the same patient. a.u.: Arbitrary unit; CRC: Colorectal cancer.