Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis

Table 3 Subgroup and meta-regression analyses

Covariates	Subgroup	No.	HR (95% CI)	Heterogeneity			Meta-regression
				Pa	I2	Pb	Crude P	Adjusted P
Treatment	Resection	4	4.46 (1.57-12.65)	0.012	72.4	0.005	0.048	0.212
	RFA	8	1.43 (1.24-1.65)	0.283	18.6
	Resection+RFA	4	1.26 (1.03-1.55)	0.532	0
	Others	2	1.43 (0.96-2.11)	0.916	0
Follow-up	≥ 36	9	1.71 (1.25-2.35)	0.000	73.4	0.454	0.596	0.989
(mo)	< 36	9	1.35 (1.17-2.56)	0.859	0
Confounder	Adjusted	9	1.70 (1.30-2.22)	0.004	64.1	0.198	0.345	0.863
	Unadjusted	9	1.37 (1.12-1.68)	0.225	24.6
Recurrence type	Overall	13	1.51 (1.21-1.87)	0.005	57.6	0.351	0.720	0.999
	Distant	5	1.64 (1.25-2.14)	0.247	26.1
Recruited	≥ 150	9	1.49 (1.26-1.69)	0.103	39.7	0.600	0.443	0.944
No.	< 150	9	1.78 (1.10-2.88)	0.007	61.8

^aP value for Q statistic of between-study heterogeneity in each subgroup; ^bP value for Q statistic of heterogeneity between the subgroups.