Seroepidemiology of hepatitis B virus infection and impact of vaccination

Table 5 Cumulative effects of familial history of hepatitis B virus on hepatitis B virus infection

Variables	HBsAg negative	HBsAg positive	OR (95%CI)	P value
Mother	1031	317	3.57 (3.12-4.08)	< 0.001
Father	2488	432	1.95 (1.75-2.17)	< 0.001
Spouse (≥ 20 yr)	3363	531	1.02 (1.00-1.04)	0.041
Offspring (≥ 20 yr)	1817	283	1.61 (1.41-1.83)	< 0.001
Siblings	1059	353	3.10 (2.73-3.51)	< 0.001
Other families	1061	130	1.57 (1.30-1.89)	< 0.001
Combined familial history of HBV and HBV infection
0	123472 (92.29)	9525 (84.88)	1	-
1	9838 (7.36)	1562 (13.95)	1.93 (1.82-2.05)	< 0.001
2	462 (0.34)	121 (1.05)	3.19 (2.60-3.92)	< 0.001
3-6	19 (0.01)	14 (0.12)	9.82 (4.80-20.11)	< 0.001
Trend				< 0.0011
0	123472 (92.29)	9525 (84.88)	1	-
1-6	10319 (7.71)	1697 (15.12)	2.00 (1.89-2.12)	< 0.001

¹The P value of Cochran-Armitage’s trend test. Logistic regression analyses adjusted for age, sex, and immunization history of HBV.