Clinical predictors of thiopurine-related adverse events in Crohn's disease

Table 3 Multivariate analysis

Adjust variables	Crude analysis	Adjusted analysis
Total (n = 351)
Age starting thiopurine older than 40 vs 40 or younger	OR (95%CI)
Female	3.6 (1.9-7.1)	4.0 (1.9-8.3)
Male	1.2 (0.6-2.6)	1.3 (0.6-3.0)

Predictors of thiopurine-related adverse events as determined by multivariate analysis. A significant age-by-gender interaction was observed in both crude and adjusted analyses, P-value = 0.03 and 0.04 respectively.