NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease

Table 5 Hardy-Weinberg equilibrium and the P value

		NOD2 polymorphisms
		p.Arg702Trp				p.Gly908Arg				p.Leu1007fsinsC
Groups	Genotypes	CC	CT	TT	P value	GG	GC	CC	P value	WT/WT	insC/WT	insC/insC	P value
	Frequencies
HC	Observed	92.98	3.51	3.51	0	96.49	3.51	0	0.8488	98.25	1.75	0	0.9247
	Expected	89.75	9.97	0.28		96.52	3.45	0.03	NS	98.25	1.74	0	NS
CD	Observed	87.21	10.46	2.33	0.0117	94.19	5.81	0	0.7813	95.35	4.65	0	0.8252
	Expected	86.92	12.62	0.46		94.27	5.64	0.08	NS	95.41	4.54	0.05	NS
IBD	Observed	90.15	8.33	1.52	0.0106	95.45	4.55	0	0.7893	95.45	4.55	0	0.7893
	Expected	88.96	10.72	0.32		95.51	4.44	0.05	NS	95.51	4.44	0.05	NS

CD: Crohn's disease; HC: Healthy controls; IBD: İnflammatory bowel disease; NS: Non-significant P value; WT: Wild type; insC: Insertion mutation of a C.