NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease

Table 3 NOD2 Allele frequencies in Crohn's disease, ulcerative colitis and healthy control groups

Polymorphisms		Allele frequency (%)
		CD	UC	HC	IBD	P value1	OR	P value2	OR	P value3	OR	P value4	OR
		(n = 86)	(n = 46)	(n = 114)	(n = 132)		(95%CI)		(95%CI)		(95%CI)		(95%CI)
p.Arg702Trp (C/T)	C	92	98	95	94	0.09	3.67	0.40	1.47	1.00	0.92	0.36	2.5
	T	8	2	5	6		0.48-4.87		0.65-3.31		0.42-2.01		0.54-11.4
p.Gly908Arg (G/C)	G	97	99	98	98	0.66	2.72	0.50	1.67	0.75	0.76	1.00	1.62
	C	3	1	2	2		0.31-23.69		0.44-6.34		0.21-2.75		0.17-14.74
p.Leu1007fsinsC (WT/insC)	WT	98	98	99	98	1.00	1.07	0.40	2.69	0.29	0.38	0.32	0.39
	insC	2	2	1	2		0.19-5.9		0.48-14.87		0.07-1.9		0.05-2.87
Total frequency (%)		13	5	8	10	0.08	0.39	0.12	1.71	0.43	1.32	0.63	0.67
							0.14-1.07		0.88-3.3		0.71- 2.48		0.24-1.86

¹The P value for CD patients vs UC patients;

²The P value for CD patients vs HC group;

³The P value for IBD patients vs HC group;

⁴The P value for UC patients vs HC group. (%) represents allele frequency. CD: Crohn's disease; UC: Ulcerative colitis; IBD: İnflammatory bowel disease (CD + UC patients); HC: Healthy controls; WT: Wild type allele; insC: Insertion mutation of a C.