Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury

Table 1 Differences in the prevalence of endoscopic ulcers and erosions in low-dose aspirin users between Western countries and Japan

Ref.	Countries	Study design	Sample size	Definition of ulcers	Prevalence of ulcers	Prevalence of ulcers and/or erosions
Kordecki et al[11], 1997	Poland	Prospective	96	Greater than 5 mm	-	68.0%
Pilotto et al[12], 2004	Italy	Prospective	245		25.7%	-
Yeomans et al[13], 2005	Australia, United Kingdom Canada, Spain,	Prospective	187	Greater than 3 mm	10.7%	-
Niv et al[14], 2005	Israel	Prospective	46	Greater than 3 mm	39.1%	47.8%
Subtotal			478 ulcers, 142 ulcers and/or erosions		21.1%	61.2%
Shiotani et al[15], 2009	Japan	Prospective	305	Greater than 5 mm	12.4%	-
Nema et al[16], 2009	Japan	Prospective	236	Greater than 5 mm	11.0%	48.4%
Kawai et al[17], 2010	Japan	Prospective	101	Greater than 3 mm	15.8%	-
Tamura et al[18], 2011	Japan	Prospective	150	Greater than 3 mm	4.0%	37.3%
Fujisawa et al[19], 2011	Japan	Retrospective	1213	Greater than 5 mm	5.9%	57.3%
Kawamura et al[20], 2013	Japan	Retrospective	226	Greater than 5 mm	6.2%	-
Uemura et al[21], 2014	Japan	Prospective	1454	Greater than 5 mm	6.5%	29.2%
Subtotal			3685 for ulcers, 3053 for ulcers and/or erosions		7.2%	36.1%