Gene polymorphisms associated with functional dyspepsia

Table 2 Genetic association studies in functional dyspepsia involving gene polymorphisms related to inflammation or immune response

Ref.	Study origin	FD subjects/controls, n	Studied gene polymorphism	Disease association
Tahara et al[78]	Japan	108/99	CD 14	No association
Arisawa et al[82]	Japan	90/188	MIF G173C	EPS, especially in H. pylori (+)
			173C
Arisawa et al[82]	Japan	90/188	IL-17A	No association
Arisawa et al[82]	Japan	90/188	IL17F	EPS in H. pylori (+)
			7488T
Tahara et al[86]	Japan	134/112	RANTES promoter C-28G	Reduced risk for PDS, especially in H. pylori (+)
			G carrier
Tahara et al[94]	Japan	111/106	TLR2	Inverse association with FD and PDS in H. pylori (+)
			-196 to -174
Tahara et al[94]	Japan	111/106	MBL2	No association
Tahara et al[95]	Japan	89/95	C242T p22PHOX	Inversely related to FD in H. pylori (+)
Arisawa et al[96]	Japan	87/185	COX-1	EPS in females
Park et al[99]	South Korea	89/180	NOS	FD
			T allele

FD: Functional dyspepsia; EPS: Epigastric pain syndrome; PDS: Postprandial distress syndrome.