Integrin αvβ6 sustains and promotes tumor invasive growth in colon cancer progression

Figure 1 Representative immunohistochemistry examples for both integrin αvβ6 and matrix metalloproteinase-9 in colon cancer. Negative expression for integrin αvβ6 (A), low integrin αvβ6 expression in the tumor edge portion (B) and high integrin αvβ6 expression in the tumor central area (C). In the paired serial sections, (D) is a negative control. Positive αvβ6 expression in the edge of both invasive tumor islands and tumor budding are shown in (E). Strong matrix metalloproteinase-9 expression (F) was also identified in invasive tumor edge portions. A scale bar is shown in the right lower corner of each figure.