Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance

Figure 1 Effect of soy extracts on concanavalin A immune mediated liver injury. A: Combination of soy extracts in doses of 3 μg and 30 μg of both OS and M1, administered to mice injected with concanavalin A (ConA), significantly decrease aspartate aminotransferase and alanine aminotransferase serum levels (^aP < 0.04, ^bP < 0.01, ^cP < 0.004 vs control); B: The combination of OS and M1 soy extracts in all doses and 3 μg M1 were associated with significant reduction of serum interferon gamma levels measured by ELISA at the end of the treatment period (^aP < 0.02, ^bP < 0.005, ^cP = 0.001 vs control); C: All combinations of soy extracts were associated with a significant decrease in serum TNF-α serum levels measured by ELISA at the end of the study (^aP < 0.005, ^bP = 0.0001, ^cP = 0.00001 vs control). AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.