Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases

Figure 1 Genome structure of hepatitis B virus with proposed microRNA target sites. A: The partially double-stranded DNA genome of hepatitis B virus (HBV) is depicted at the center, surrounded by the overlapping open-reading frames (ORFs) (thick colored arrows). The outer, black arrows represent the viral mRNA transcripts; B: Linear arrangement of overlapping ORFs and viral transcripts. Transcripts and ORF are aligned with each other according to genomic location and are to scale. Colored boxes on transcripts indicate proposed miRNA target sites discussed in the text.