Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases

doi:10.3748/wjg.v21.i24.7584

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2015; 21(24): 7584-7588
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7584

Table 2 Clinical characteristics of patients in published cases

Case - Year	Age/Gender	Disease	Anti-TNF drug	Immunosuppressant	Dose mg/kg/n-infusions	Symptoms	Autoantibodies	Histology	Steroid response	Outcome
2007³	56/F	AS	IFX	None	5/6	Yes	Anti-dsDNA, ANA, ASMA	Piecemeal necrosis	Yes	Reversibility
2005⁴	53/F	PsA	IFX	MTX	3/8	No	Anti-dsDNA, ANA, ASMA	Severe interface hepatitis	Yes	Reversibility
2007¹²	54/F	RA	IFX	MTX	3/12	No	ANA	Chronic inflammation	Yes	Reversibility
2010⁷	60/M	CD	IFX	None	5/4	No	Anti-dsDNA, ANA, ASMA	Interface hepatitis	Yes	Reversibility
2009⁸	22/F	PPP	IFX	None	5/3	No	None	Interface hepatitis	Yes	Reversibility
2010¹⁰	40/F	PsO, PsA	IFX	NSAIDS	5/5	Yes	Anti-dsDNA, ANA	Chronic hepatitis with portal+periportal fibrosis	Yes	Reversibility
2010⁹	37/M	PsO	IFX	None	5/3	Yes	Anti-dsDNA, ANA, ASMA Anti-dsDNA, ANA, AMA, anti-cardiolipin	Interface hepatitis	Yes	Reversibility
2010⁹	51/M	PsO	IFX	None	5/3	Yes		Interface hepatitis + PBC Overlap syndrome	Yes	Reversibility
2001¹¹	36/F	RA	IFX	PDN 10 mg	3/3	Yes	Anti-dsDNA, ANA	Interface hepatitis	Yes	Reversibility
2010⁶	36/F	PsA, PsO, CD	ADA	None	40 mg EOW 6^th injection	Yes	Anti-dsDNA, ANA	Interface hepatitis	Yes	Reversibility
2012¹²	46/F	CD	IFX	None	5/3	No	ANA, ASMA	Interface hepatitis	Yes	Reversibility
2008⁵	30/F	UC	IFX	AZA	10/> 15	No	ANA,Anti-dsDNA	Interface hepatitis	Yes	Reversibility

AS: Ankylosing spondylitis; PsA: Psoriatic arthritis; RA: Rheumatoid arthritis; CD: Crohn’s disease; PPP: Palmoplantar pustular psoriasis; PsO: Psoriasis; IFX: Infliximab; ADA: Adalimumab; MTX: Methotrexate; AZA: Azathioprine; EOW: Every other week; dsDNA: Double stranded DNA; ASMA: Anti-smooth muscle antibodies; AMA: Anti-mitochondrial antibodies; PDN: Prednisolone; NSAIDs: Non-steroidal anti-inflammatory drugs; PBC: Primary biliary cirrhosis.

Citation: Rodrigues S, Lopes S, Magro F, Cardoso H, Horta e Vale AM, Marques M, Mariz E, Bernardes M, Lopes J, Carneiro F, Macedo G. Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases. World J Gastroenterol 2015; 21(24): 7584-7588
URL: https://www.wjgnet.com/1007-9327/full/v21/i24/7584.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i24.7584