Copyright
©The Author(s) 2015.
World J Gastroenterol. Jun 28, 2015; 21(24): 7584-7588
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7584
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7584
Age/Gender | Disease/Disease duration | Anti-TNF drug | Dose mg/kg/number infusions/injections | Concomitant drugs | Symptoms | Transaminase levels (ALT/AST - x ULN) | Autoantibodies/ Immunoglobulins | Histology | AIH scorePost-therapy | Steroid response | Maintenance therapy | Outcome |
1 - 36F | Distal UC/7 yr | IFX | 5 mg/kg/5 | Mesalamine | Yes | 14/9 | Anti-dsDNA, ANA, High IgG | Interface hepatitis | 20 | Yes | Mesalamine 3 g/d PO | Reversibility |
2 - 45F | RA/10 yr | ADA | 40 mg EOW/11 | MTX NSAIDs | No | 4.5/3 | ANA, High IgG | Severe interface hepatitis | 19 | Yes | AZA 50 mg, ETC, Prednisolone 7.5 mg | Reversibility |
3 - 34F | Distal UC/2 yr | IFX | 5 mg/kg/8 | Mesalamine | Yes | 4.5/3 | ANA, High IgG | Interface hepatitis | 20 | Yes | Mesalamine 3 g/d PO | Reversibility |
4 - 35M | Extensive UC/2 yr | IFX | 5 mg/kg/8 | Mesalamine | No | 13/7 | ANA, High IgG | Interface hepatitis/marginal proliferation of bile ducts | 20 | Yes | Mesalamine 3 g/d PO | Controlled on therapy |
AZA 2.5 mg/kg per day | ||||||||||||
5 - 43M | AS/30 yr | IFX | 5 mg/kg/5 | - | No | 25/15 | High IgG | Interface hepatitis/cirrhosis | 20 | Yes | AZA 50 mg, Prednisolone 10 mg | Controlled on therapy |
6 - 66F | Ileal CD/11 yr | IFX | 5 mg/kg/13 | Mesalamine, AZA | No | 2/5 | ANA | Chronic lymphoplasmocytic infiltrate | 19 | Yes | IFX 5 mg/kg AZA 2.5 mg/kg per day | Reversibility |
7 - 37M | Ileal CD/2 yr | IFX | 5 mg/kg/12 | Mesalamine (suspended INH 2 mo prior to IFX) | No | 4/2 | ANA, High IgG | Interface hepatitis | 20 | Yes | Mesalamine 3 g/d PO | Reversibility |
8 - 69F | Ileal CD/32 yr | IFX | 5 mg/kg/4 | Mesalamine | No | 10/5 | ANA | Interface hepatitis | 19 | Yes | Mesalamine 3 g/d PO | Reversibility |
- Citation: Rodrigues S, Lopes S, Magro F, Cardoso H, Horta e Vale AM, Marques M, Mariz E, Bernardes M, Lopes J, Carneiro F, Macedo G. Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases. World J Gastroenterol 2015; 21(24): 7584-7588
- URL: https://www.wjgnet.com/1007-9327/full/v21/i24/7584.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i24.7584