Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea

doi:10.3748/wjg.v21.i24.7563

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2015; 21(24): 7563-7570
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7563

Table 4 Sensitivity, specificity, positive predictive value, negative predictive value of 4-sample lactose hydrogen breath testing method using standard lactose hydrogen breath test method as the reference

	LHBT		Sensitivity	Specificity	PPV	NPV
IBS-D	10 g	LM	92%	100%	100%	94.6%
		LI	91%	100%	100%	98%
	20 g	LM	96%	100%	100%	80%
		LI	93%	100%	100%	94.1%
	40 g	LM	98%	100%	100%	80%
		LI	94%	100%	100%	76.9%
HVs	10 g	LM	90%	100%	100%	95.1%
		LI	100%	100%	100%	100%
	20 g	LM	96%	100%	100%	85.7%
		LI	92%	100%	100%	97.9%
	40 g	LM	96%	100%	100%	71.4%
		LI	93%	100%	100%	86.4%

LHBT: Lactose hydrogen breath test; LM: Lactose malabsorption; LI: Lactose intolerance; 4SLHBT: 4-Sample Lactose Hydrogen Breath Testing; IBS-D: Irritable bowel syndrome patients with diarrhea; HVs: Healthy volunteers; PPV: Positive predictive value; NPV: Negative predictive value.

Citation: Yang JF, Fox M, Chu H, Zheng X, Long YQ, Pohl D, Fried M, Dai N. Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea. World J Gastroenterol 2015; 21(24): 7563-7570
URL: https://www.wjgnet.com/1007-9327/full/v21/i24/7563.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i24.7563