Retrospective Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jun 28, 2015; 21(24): 7506-7513
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7506
Table 3 Univariate and multivariate analysis of risk factors for organ failure in patients with bacteriobilia who underwent percutaneous transhepatic biliary drainage because of acute cholangitis (n = 130) n (%)
FactorUnivariate analysis
Multivariate analysis
Patients with OF (n = 22)Patients without OF (n = 108)P valueOR (95%CI)P value
Age ≥ 65 yr14 (63.6)57 (52.8)0.351
Male/female11/1164/440.423
Heavy smoker10 (0.0)10 (9.3)0.211
Heavy alcohol drinker21 (4.5)6 (5.6)1.000
Body temperature > 38 or < 36  °C8 (36.4)33 (30.6)0.593
Positive Charcot’s triad3 (13.6)13 (12.0)0.734
Symptom to door time (h)196.6 ± 88.899.4 ± 175.20.106
CCIs ≥ 410 (45.5)65 (60.2)0.202
Pre-existing renal dysfunction7 (31.8)4 (3.7)0.00096.319 (1.348-29.629)0.0199
Etiology
Choledocholithiasis11 (50.0)25 (23.1)0.01093.573 (1.195-10.686)0.0239
Benign biliary stricture2 (9.1)17 (15.7)0.528
Malignant biliary obstruction9 (40.9)62 (57.4)0.157
Procedure-related0 (0.0)4 (3.7)1.000
Laboratory finding
WBC > 12000 or < 4000/mm313 (59.1)44 (40.7)0.114
Total bilirubin ≥ 5 mg/dL10 (45.5)32 (29.6)0.148
ALP ≥ 250 IU/L14 (63.6)60 (55.6)0.485
Albumin ≤ 2.8 g/dL13 (59.1)36 (33.3)0.0239
C-reactive protein ≥ 5 mg/dL16 (76.2)74 (69.8)0.557
The severity of acute cholangitis3
Mild5 (22.7)40 (37.0)0.198
Moderate7 (31.8)41 (39.9)0.586
Severe10 (45.5)27 (25.0)0.053
Bile culture-Causative microorganism
Escherichia coli4 (18.2)15 (13.9)0.740
Klebsiella species2 (9.1)7 (6.5)0.648
Pseudomonas species1 (4.5)10 (9.3)0.689
Enterobacter species0 (0.0)2 (1.9)1.000
Enterococcus species5 (22.7)9 (8.3)0.062
Other organism2 (9.1)9 (8.3)1.000
Multiorganism8 (36.4)56 (51.8)0.185
Bile culture-ESBL3 (13.0)11 (9.6)0.705
Bile culture-MRSA1 (4.3)3 (2.6)0.528
Bile culture-Antibiotic resistance410 (45.5)52 (48.1)0.818
Positive blood culture8 (36.4)36 (33.3)0.784
Blood culture-Causative microorganism
Escherichia coli5 (62.5)18 (50.0)0.542
Klebsiella species1 (12.5)9 (25.0)1.000
Pseudomonas species1 (12.5)5 (13.9)1.000
Other organism0 (0.0)3 (8.3)1.000
Multiorganism1 (12.5)1 (2.8)0.311
Blood culture-ESBL3 (13.6)2 (1.9)0.034915.376 (1.748-135.267)0.0149
Blood culture-Antibiotic resistance53 (13.6)5 (4.6)0.133
Same microorganisms64 (50.0)16 (44.4)0.747
Unsuccessful biliary decompression74 (18.2)8 (7.4)0.121
Visit to decompression time (h)821.6 ± 13.016.7 ± 11.30.103