Prognostic factors of spontaneously ruptured hepatocellular carcinoma

Table 2 Multivariate analysis of risk factors related to survival in patients with hepatocellular carcinoma rupture

Variables	HR	95%CI	P value
Age (yr)	0.96	0.93-1.00	0.026
Lesion length (cm)	1.46	1.23-1.73	< 0.001
Number	1.37	1.01-1.85	0.042
Cirrhosis (presence)	2.47	0.77-7.96	0.131
BCLC stage A (control)	-	-	-
BCLC stage B	0.10	0.02-0.41	0.002
BCLC stage C	0.19	0.03-1.01	0.052
Treatment before rupture (presence)	4.36	1.27-14.99	0.019
Treatment in follow-up period (presence)	0.21	0.07-0.67	0.008
WBC, × 109/L	1.04	0.96-1.13	0.375
HB, g/L	0.99	0.97-1.00	0.314
PLT, × 1010/L	1.00	0.99-1.00	0.143
INR	0.39	0.04-3.60	0.406
APTT, S	1.07	0.99-1.15	0.103
ALT, U/L	1.00	1.00-1.01	0.011
ALB, g/L	0.89	0.81-0.97	0.010
TBil, umol/L	1.00	0.97-1.02	0.735
HCO3-, mmol/L	1.18	1.08-1.28	< 0.001
Crea, umol/L	1.01	1.00-1.02	0.089
Child-Pugh	1.03	0.59-1.80	0.905

WBC: White blood cell count; HB: Hemoglobin; PLT: Platelet count; INR: International normalized ratio; APTT: Activated partial thromboplastin time; ALT: Alanine transaminase; ALB: Albumin; TBil: Total bilirubin; HCO₃^-: Bicarbonate; Crea: Creatinine.